HTR5A

Description

The HTR5A (5-hydroxytryptamine receptor 5A) is a protein-coding gene located on chromosome 7.

The HTR5A gene encodes a protein that acts as a receptor for 5-hydroxytryptamine (serotonin). It is a member of the 5-hydroxytryptamine receptor family and is a multi-pass membrane protein that couples to G proteins, negatively impacting cAMP levels. This protein regulates intracellular Ca2+ mobilization. The HTR5A receptor is functional in a native expression system. While rodents possess two functional 5-HT5 receptor subtypes, 5-HT5A and 5-HT5B, humans only express the 5-HT5A subtype. The HTR5A receptor also acts as a presynaptic serotonin autoreceptor. Serotonin is involved in various psychiatric conditions and has vasoconstrictive and vasodilatory effects. Few selective ligands for the 5-HT5A receptor are commercially available. To activate this receptor in scientific research, the non-selective serotonin receptor agonist 5-Carboxamidotryptamine can be used in combination with selective antagonists for its other targets (primarily 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT7).

HTR5A is also known as 5-HT5A.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing