HTR4
Description
The HTR4 (5-hydroxytryptamine receptor 4) is a protein-coding gene located on chromosome 5.
HTR4 is a human gene that encodes a serotonin receptor. This receptor is a G protein-coupled receptor that stimulates cAMP production in response to serotonin. The encoded protein is glycosylated and functions in both the peripheral and central nervous system to modulate neurotransmitter release. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some variants remains unclear. The receptor is found in the alimentary tract, urinary bladder, heart, adrenal gland, and central nervous system. Within the CNS, it is present in the putamen, caudate nucleus, nucleus accumbens, globus pallidus, and substantia nigra, and to a lesser extent in the neocortex, raphe, pontine nuclei, and certain areas of the thalamus. It is not found in the cerebellum. Internalization of the receptor is isoform-specific. Several drugs that act as selective 5-HT4 agonists are used in both research and clinical medicine. Some of these drugs, such as mosapride, metoclopramide, renzapride, and zacopride, also act as 5-HT3 antagonists, making them not fully selective.
HTR4 is a G protein-coupled receptor that binds to serotonin (5-hydroxytryptamine) and activates adenylate cyclase.
HTR4 is also known as 5-HT4, 5-HT4R.
