HTR3A

Description

The HTR3A (5-hydroxytryptamine receptor 3A) is a protein-coding gene located on chromosome 11.

HTR3A is a gene that encodes the 5-hydroxytryptamine receptor 3A protein, a member of the ligand-gated ion channel receptor superfamily. This protein forms the type 3 receptor for serotonin (5-hydroxytryptamine), a crucial neurotransmitter, hormone, and mitogen. Activation of the HTR3A receptor leads to rapid depolarizing responses in neurons. HTR3A can exist as a homomer, with only the A subunit, or as a heteromer, when combined with other subunits like HTR3B. Homomeric complexes have very low single channel conductance (0.6pS), while heteromeric complexes exhibit significantly higher conductance. Alternative splicing generates different isoforms of the HTR3A protein.

The HTR3A protein forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes. Upon activation, these complexes cause fast, depolarizing responses in neurons. This function is supported by multiple studies (PubMed:10521471, PubMed:12867984, PubMed:17392525, PubMed:9950429).

HTR3A is also known as 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3.

Associated Diseases

• cancer
• schizophrenia
• major depressive disorder
• migraine disorder
• depressive disorder
• ileus
• prostate cancer