HTR1E
Description
The HTR1E (5-hydroxytryptamine receptor 1E) is a protein-coding gene located on chromosome 6.
The HTR1E gene encodes a highly conserved G-protein coupled receptor, 5-HT1E, belonging to the 5-HT1 receptor family. Its function is unknown due to a lack of selective tools and models. However, its high conservation suggests a vital role. The receptor is particularly abundant in memory-related brain regions, including the frontal cortex, hippocampus, and olfactory bulb, leading to the hypothesis that it regulates memory. Interestingly, this gene is absent in rodents, but found in other species like pigs, monkeys, and guinea pigs. This makes the guinea pig a potential model for studying HTR1E function. Expression of the receptor undergoes significant changes during human adolescence, particularly in correlation with 5-HT1B expression. The HTR1E receptor shares significant homology with the 5-HT1F receptor, suggesting similar pharmacological characteristics.
The HTR1E gene encodes a G-protein coupled receptor for serotonin (5-hydroxytryptamine). It also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding triggers signaling via G proteins, modulating the activity of downstream effectors like adenylate cyclase. This signaling inhibits adenylate cyclase activity.
HTR1E is also known as 5-HT1E.
