HTATIP2
Description
The HTATIP2 (HIV-1 Tat interactive protein 2) is a protein-coding gene located on chromosome 11.
HTATIP2 is an enzyme that is encoded by the HTATIP2 gene in humans. It may be a metastasis suppressor.
HTATIP2 is an oxidoreductase that plays a role in tumor suppression. When bound to NADPH, it inhibits nuclear import by competing with other molecules for binding to certain nuclear transport receptors. This suggests that HTATIP2 might act as a redox sensor, influencing gene expression through its control over nuclear import. HTATIP2 exists in two isoforms. Isoform 1 is a metastasis suppressor, promoting cell death and inhibiting blood vessel formation. Isoform 2, in contrast, has an anti-apoptotic effect.
HTATIP2 is also known as CC3, SDR44U1, TIP30.
Associated Diseases
- attenuated familial adenomatous polyposis
- myofibromatosis, infantile, 1
- Li-Fraumeni syndrome
- cancer
- familial atypical multiple mole melanoma syndrome
- Ollier disease
- Maffucci syndrome
- Muir-Torre syndrome
- gastric adenocarcinoma and proximal polyposis of the stomach
