HSPB7
Description
The HSPB7 (heat shock protein family B (small) member 7) is a protein-coding gene located on chromosome 1.
Human HSPB7, also known as Heat Shock Protein Family B (small) member 7, is encoded by a gene with four exons located on chromosome 1p36.13. This protein contains 170 amino acids and has a molecular weight of 18,611 Da. It belongs to the human small heat shock protein (HSPB) family, which includes eleven chaperone proteins. HSPB7 is located near its gene pair SRARP on chromosome 1p36.13. HSPB7 is widely expressed throughout the body, with the highest expression observed in cardiac tissue. It plays a protective role against aggregation of proteins with extended polyglutamine (polyQ) stretches, which are associated with neurodegenerative diseases. Within the HSPB family of chaperones, HSPB7 is the most potent suppressor of polyQ aggregation. HSPB7 contains a HSP20 domain and interacts strongly with the chaperone protein 14-3-3, a common feature shared with SRARP proteins. HSPB7 has cardiac protective functions, and mutations in its gene can lead to cardiomyopathies. Its cardioprotective function is believed to be mediated by facilitating sarcomeric proteostasis.
HSPB7 is also known as cvHSP.
