HSPB6
Description
The HSPB6 (heat shock protein family B (small) member 6) is a protein-coding gene located on chromosome 19.
HSPB6 is a protein encoded by the HSPB6 gene in humans. It's a 17 kDa member of the heat shock protein family, initially discovered in 1994. HSPB6 is expressed in multiple tissues, with the highest levels found in vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle, and skeletal muscle. It has specific functions related to vasodilation, platelet function, insulin resistance, and muscle function in both smooth and cardiac muscle.
HSPB6 is a molecular chaperone that helps to refold denatured proteins. It plays a role in various biological processes, including regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. HSPB6 may also regulate myocardial angiogenesis through its interaction with KDR. Overexpression of HSPB6 can protect the heart and promote angiogenesis after damage. HSPB6 interacts with and stabilizes YWHAZ, supporting YWHAZ's chaperone-like activity.
HSPB6 is also known as HEL55, Hsp20, PPP1R91.
Associated Diseases
- breast cancer
- dehydrated hereditary stomatocytosis
- cancer
- retinitis pigmentosa and erythrocytic microcytosis
- hemoglobin D disease
- sitosterolemia
- hemoglobin E-beta-thalassemia syndrome
- familial hypobetalipoproteinemia 1
- diabetes mellitus, permanent neonatal 4
