HSPB11
Heat Shock Protein B11 (HSPB11)
Description:
Heat shock protein B11 (HSPB11), also known as HSP22, is a member of the small heat shock protein family. These proteins are highly conserved across species and play essential roles in protecting cells against various cellular stresses, including heat shock, oxidative stress, and heavy metals.
HSPB11 is primarily localized to the cytoplasm and nucleus, where it forms multimeric complexes with other chaperones. It exhibits ATP-independent chaperone activity, preventing protein aggregation and assisting in protein folding and refolding.
Associated Diseases:
HSPB11 has been implicated in the pathogenesis of several diseases, including:
- Cancer: Overexpression of HSPB11 has been observed in various types of cancer, such as breast cancer, lung cancer, and colon cancer. It is thought to contribute to tumor growth, migration, and resistance to chemotherapy.
- Neurological disorders: HSPB11 deficiency has been associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It is believed to play a protective role against neuronal damage.
- Cardiovascular diseases: HSPB11 has been implicated in heart failure and myocardial infarction. Its overexpression may contribute to cardiac dysfunction and remodeling.
- Immunological disorders: HSPB11 has immunomodulatory properties and has been linked to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Did you Know ?
- Researchers have found that high levels of HSPB11 in tumor cells are associated with a poorer prognosis and reduced survival rates in cancer patients.
