HSD17B7
Understanding HSD17B7: The Enzyme with a Critical Role in Hormone Metabolism
Description
HSD17B7 is an enzyme responsible for metabolizing various steroid hormones, including estrogens and androgens. It is primarily expressed in the placenta, ovaries, testes, and brain, where it plays crucial roles in hormonal regulation. HSD17B7 catalyzes the conversion of estrone to estradiol, the biologically active form of estrogen, and the transformation of androstenedione to testosterone, the primary male sex hormone.
Associated Diseases
Dysregulation of HSD17B7 activity has been linked to several medical conditions:
- Preeclampsia: HSD17B7 deficiency in the placenta can disrupt estrogen metabolism, leading to endothelial dysfunction and increased risk of preeclampsia, a severe pregnancy complication.
- Breast Cancer: Elevated HSD17B7 expression in breast tissue can promote estrogen-dependent tumor growth.
- Prostate Cancer: HSD17B7 inhibition has shown potential in reducing testosterone levels and slowing prostate cancer progression.
- Polycystic Ovary Syndrome (PCOS): HSD17B7 overactivity in the ovaries may contribute to hormonal imbalances and insulin resistance characteristic of PCOS.
- Neurological Disorders: HSD17B7 is essential for the development and maintenance of the central nervous system. Mutations in the HSD17B7 gene have been associated with neurodevelopmental disorders and cognitive impairments.
Did you Know ?
In women with preeclampsia, HSD17B7 activity in the placenta can be reduced by up to 50%, highlighting the significant impact of this enzyme on pregnancy outcomes.
