HSD17B12
HSD17B12: An Essential Enzyme in Cholesterol Metabolism
Description
HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12) is an enzyme that plays a crucial role in the metabolism of cholesterol, a vital molecule for cell structure and function. It specifically catalyzes the conversion of 17-beta-hydroxysteroids, including estradiol and testosterone, into their inactive 17-ketosteroid forms. This process is essential for maintaining proper hormone balance and preventing excessive accumulation of these steroids in the body.
Associated Diseases
Dysregulation of HSD17B12 activity has been linked to several diseases, including:
- Polycystic Ovary Syndrome (PCOS): PCOS is a hormonal disorder characterized by irregular periods, infertility, and weight gain. Studies have shown that women with PCOS often have increased HSD17B12 activity, leading to elevated levels of testosterone and other androgens.
- Endometrial Cancer: HSD17B12 is expressed in endometrial cells, and its overexpression has been associated with an increased risk of endometrial cancer.
- Breast Cancer: HSD17B12 is involved in the metabolism of estradiol, a key hormone in breast cancer development. Abnormal HSD17B12 activity may contribute to the growth and progression of breast cancer.
Did you Know ?
According to a study published in the journal "Endocrinology," women with PCOS have approximately a 20% higher level of HSD17B12 activity compared to healthy women. This elevation in enzyme activity contributes to the hormonal imbalances characteristic of PCOS.
