HS3ST5
Description
The HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5) is a protein-coding gene located on chromosome 6.
HS3ST5 is a sulfotransferase that uses 3'-phospho-5'-adenylyl sulfate (PAPS) to add a sulfate group to position 3 of glucosamine residues in heparan. This enzyme catalyzes the rate-limiting step in heparan sulfate biosynthesis, which is crucial for producing anticoagulant heparan sulfate. Specifically, it completes the structure of the antithrombin pentasaccharide binding site. HS3ST5 also generates GlcUA-GlcNS, IdoUA-GlcNS, and IdoUA2S-GlcNH2. The substrate-specific O-sulfation results in an enzyme-modified heparan sulfate that serves as a receptor for Herpes simplex virus-1 (HSV-1), enabling viral entry.
HS3ST5 is also known as 3-OST-5, 3OST5, HS3OST5, NBLA04021.
