HS3ST3B1
Description
The HS3ST3B1 (heparan sulfate-glucosamine 3-sulfotransferase 3B1) is a protein-coding gene located on chromosome 17.
HS3ST3B1 is an enzyme that is encoded by the HS3ST3B1 gene in humans. It plays a role in heparan sulfate biosynthesis, which involves the creation of various heparan sulfate structures with diverse biological activities. HS3ST3B1 is part of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and has heparan sulfate glucosaminyl 3-O-sulfotransferase activity, similar to HS3ST3A1. The Sulfotransferase domain of HS3ST3B1 is highly similar to the same domain in HS3ST3A1, and both enzymes sulfate the same disaccharide. HS3ST3B1 is expressed in various tissues, with the highest levels found in the liver and placenta.
HS3ST3B1 is a sulfotransferase that uses 3'-phospho-5'-adenylyl sulfate (PAPS) to transfer a sulfate group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. It catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and IdoUA2S-GlcNH2. The specific O-sulfation by HS3ST3B1 creates a modified heparan sulfate that acts as a receptor for Herpes simplex virus-1 (HSV-1), allowing the virus to enter cells. Unlike HS3ST1/3-OST-1, HS3ST3B1 does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
HS3ST3B1 is also known as 3-OST-3B, 3OST3B1, h3-OST-3B.
Associated Diseases
- hemoglobin D disease
- dominant beta-thalassemia
- hemoglobin H disease
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hemoglobin C-beta-thalassemia syndrome
- hemoglobin E disease
- delta-beta-thalassemia
- cyanosis, transient neonatal
- alpha-thalassemia-myelodysplastic syndrome
