HS3ST2
Description
The HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2) is a protein-coding gene located on chromosome 16.
HS3ST2 is a human gene that encodes the enzyme heparan sulfate glucosamine 3-O-sulfotransferase 2. This enzyme is involved in the biosynthesis of heparan sulfate, a complex carbohydrate molecule that plays a role in various biological processes. As a member of the heparan sulfate biosynthetic enzyme family, HS3ST2 acts as a type II integral membrane protein, possessing heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The gene's expression is primarily observed in the brain, suggesting its importance in nervous system function. Research has linked HS3ST2 to breast cancer pathogenesis. Hypermethylation of the HS3ST2 promoter in breast cancer tissue compared to normal breast ducts indicates its potential involvement in the disease. Functional analysis has demonstrated that increased HS3ST2 expression in breast cancer cells leads to altered invasiveness, potentially due to changes in mitogen-activated protein kinase signaling and matrix metalloproteinase expression.
HS3ST2 is also known as 30ST2, 3OST2.
Associated Diseases
- systemic lupus erythematosus
- cancer
- Mobius syndrome
- mitochondrial DNA depletion syndrome 4a
- colorectal cancer
- metastatic malignant neoplasm
