HRASLS
Hemolytic Reactive Leukocyte Syndrome (hRLS)
Description
Hemolytic Reactive Leukocyte Syndrome (hRLS) is a rare autosomal dominant disorder characterized by recurrent episodes of fever, chills, hemolytic anemia, and acute multi-organ inflammation. It is caused by mutations in the LRRK2 gene, which encodes a protein involved in inflammatory responses.
hRLS is characterized by a triad of symptoms:
- Fever and chills: Recurring episodes of high fever and chills
- Hemolytic anemia: Destruction of red blood cells, leading to low red blood cell counts
- Multi-organ inflammation: Inflammation in various organs, including the skin, joints, lungs, and gastrointestinal tract
Associated Diseases
hRLS is often associated with other autoimmune and inflammatory conditions, such as:
- SLE (Systemic Lupus Erythematosus)
- Rheumatoid arthritis
- Inflammatory bowel disease
- Thyroiditis
- Vasculitis
Did you Know ?
hRLS is estimated to affect 1 in 100,000 people worldwide.
