HOXC8
Description
The HOXC8 (homeobox C8) is a protein-coding gene located on chromosome 12.
HOXC8 is a human gene that encodes the Homeobox protein Hox-C8. This protein is part of the homeobox family of genes, which are known for their role in morphogenesis. HOXC8 is involved in cartilage differentiation and may be implicated in chondrodysplasias and other cartilage disorders. Its activity in promoting nerve growth has been observed, and its expression is altered in neurofibromatosis type 1. HOXC8 interacts with Mothers against decapentaplegic homolog 6 and Mothers against decapentaplegic homolog 1.
HOXC8 is a transcription factor that plays a role in development, specifically in defining the position of cells along the anterior-posterior axis of the body.
HOXC8 is also known as HOX3, HOX3A.
Associated Diseases
- breast cancer
- autosomal recessive spondylocostal dysostosis
- spondylometaphyseal dysplasia, A4 type
- thoracolaryngopelvic dysplasia
- autosomal dominant spondylocostal dysostosis
- spondyloepimetaphyseal dysplasia, Missouri type
- spondylometaphyseal dysplasia, Kozlowski type
- spondyloepimetaphyseal dysplasia, matrilin-3 type
- metatropic dysplasia
- spondyloepimetaphyseal dysplasia, Irapa type
- mesomelic dysplasia, Kantaputra type
- pseudoachondroplasia
- thoracomelic dysplasia
