HOXB9
Description
The HOXB9 (homeobox B9) is a protein-coding gene located on chromosome 17.
HOXB9 is a gene located on chromosome 17 that encodes a protein called Homeobox protein Hox-B9. This protein belongs to the Abd-B homeobox family and contains a homeobox DNA-binding domain. It functions as a transcription factor, regulating the expression of other genes by binding to specific DNA sequences. HOXB9 plays a role in cell proliferation and differentiation, and its increased expression has been linked to certain types of cancer, including leukemia, prostate cancer, and lung cancer. HOXB9 interacts with proteins BTG2 and BTG1.
HOXB9 is also known as HOX-2.5, HOX2, HOX2E.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- Alzheimer disease
- cancer
- autosomal recessive spondylocostal dysostosis
- thoracomelic dysplasia
- autosomal dominant spondylocostal dysostosis
- spondylometaphyseal dysplasia, A4 type
