HOXA-AS3
Description
The HOXA-AS3 (HOXA cluster antisense RNA 3) is a ncRNA gene located on chromosome 7.
HOXA-AS3 is a long non-coding RNA (lncRNA) that acts as a regulator of gene expression. It has been implicated in various cellular processes including proliferation, differentiation, and apoptosis. The role of HOXA-AS3 in cancer development remains controversial with studies showing both tumor-suppressive and tumor-promoting effects depending on the specific context and cellular environment.
HOXA-AS3, also known as HOTAIRM1, is a long non-coding RNA (lncRNA) that acts as a potent regulator of gene expression. Studies have shown that HOXA-AS3 exhibits both tumor-suppressive and tumor-promoting roles depending on the specific context and cellular environment. It is involved in various cellular processes, including proliferation, differentiation, and apoptosis. For instance, HOXA-AS3 has been linked to the regulation of the HOXA gene cluster, which plays a crucial role in development and differentiation. Additionally, it has been implicated in the modulation of microRNA (miRNA) activity, acting as a competing endogenous RNA (ceRNA). This means that it can bind to and sequester miRNAs, thereby preventing their interaction with target messenger RNAs (mRNAs) and affecting gene expression. In certain cancers, HOXA-AS3 is overexpressed and contributes to tumorigenesis by promoting cell proliferation and inhibiting apoptosis. Conversely, in other cancers, its downregulation is associated with tumor progression. The precise mechanisms underlying these divergent effects are still being investigated, but it highlights the complexity of HOXA-AS3's function.
HOXA-AS3 is also known as HOXA6as.
Associated Diseases
- breast cancer
- Bloom syndrome
- cancer
- Pallister-Hall syndrome
- leukocyte adhesion deficiency
- glioblastoma
- inborn error of immunity
- urinary bladder carcinoma
