HOOK3
Description
The HOOK3 (hook microtubule tethering protein 3) is a protein-coding gene located on chromosome 8.
Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene. Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.
HOOK3 acts as an adapter protein, linking the dynein motor complex to various cargos and converting dynein from a non-processive to a highly processive motor in the presence of dynactin. It facilitates the interaction between dynein and dynactin, activating dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). HOOK3 primarily recruits two dyneins, increasing both the force and speed of the microtubule motor. It is a component of the FTS/Hook/FHIP complex (FHF complex) which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). HOOK3 may also regulate clearance of endocytosed receptors like MSR1 and participates in defining the architecture and localization of the Golgi complex. The FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
HOOK3 is also known as HK3.
