HNRNPL
Description
The HNRNPL (heterogeneous nuclear ribonucleoprotein L) is a protein-coding gene located on chromosome 19.
Heterogeneous nuclear ribonucleoprotein L (hnRNP L) is a protein encoded by the HNRNPL gene. It is a component of heterogeneous ribonucleoprotein (hnRNP) complexes and plays a major role in the formation, packaging, processing, and function of mRNA. It is present in the nucleoplasm as part of the HNRP complex and is also found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. HNRNPL interacts with HNRNPLL, HNRPK, PCBP2, and PTBP1.
HNRNPL is a splicing factor that binds to exonic or intronic sites, acting as either an activator or repressor of exon inclusion. It exhibits a preference for CA-rich elements. It is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and is associated with most nascent transcripts. It interacts with APEX1 and together they bind to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex containing ZNF827, HNRNPK, and the circular RNA circZNF827, it may negatively regulate the transcription of genes involved in neuronal differentiation. It regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8.
HNRNPL is also known as HNRPL, P/OKcl.14, hnRNP-L.
