HMOX2

Description

The HMOX2 (heme oxygenase 2) is a protein-coding gene located on chromosome 16.

Heme oxygenase 2 is an enzyme that in humans is encoded by the HMOX2 gene. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 (this enzyme) belong to the heme oxygenase family.

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, releasing carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:1575508, ECO:0000269|PubMed:7890772}

HMOX2 is also known as HO-2.

Associated Diseases

• cancer
• dominant beta-thalassemia
• beta-thalassemia-X-linked thrombocytopenia syndrome
• hemoglobin D disease
• paramyotonia congenita of Von Eulenburg
• dehydrated hereditary stomatocytosis
• Thomsen and Becker disease
• hemoglobin C-beta-thalassemia syndrome
• hemoglobin H disease
• overhydrated hereditary stomatocytosis