HMGN1
Description
The HMGN1 (high mobility group nucleosome binding domain 1) is a protein-coding gene located on chromosome 21.
HMGN1 encodes a non-histone chromosomal protein called HMG-14. Along with its close relative, HMG17, it binds to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. These proteins may be involved in maintaining transcribable genes in a unique chromatin conformation. The ubiquitous distribution, relative abundance, and high evolutionary conservation of HMG14 family proteins suggest a crucial role in cellular function.
HMGN1 binds to the inner side of the nucleosomal DNA, modifying the interaction between DNA and the histone octamer. This binding may be involved in maintaining a unique chromatin conformation for transcribable genes. Additionally, HMGN1 inhibits the phosphorylation of nucleosomal histones H3 and H2A by the kinases RPS6KA5/MSK1 and RPS6KA3/RSK2.
HMGN1 is also known as HMG14.
Associated Diseases
- Dravet syndrome
- hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2
- Li-Fraumeni syndrome
