HMG20A

Description

The HMG20A (high mobility group 20A) is a protein-coding gene located on chromosome 15.

HMG20A is a human gene that encodes for the High mobility group protein 20A.

HMG20A plays a crucial role in neuronal differentiation by acting as a chromatin-associated protein. It functions as an inhibitor of HMG20B, effectively overcoming the repressive effects of the neuronal silencer REST and promoting the activation of neuronal-specific genes. HMG20A is involved in the recruitment of the histone methyltransferase KMT2A/MLL1, leading to increased methylation of histone H3 lysine 4.

HMG20A is also known as HMGX1, HMGXB1.

Associated Diseases


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