HLA DRB1

Description

The HLA-DRB1 gene, located on chromosome 6, encodes a protein that plays a crucial role in the immune system‘s response to foreign invaders. This protein, known as HLA-DRB1, is a component of the major histocompatibility complex (MHC) class II, which presents processed antigens to T lymphocytes. This interaction triggers an immune response, allowing the body to identify and eliminate harmful pathogens. The diversity in HLA-DRB1 gene alleles across individuals contributes to the immune system‘s ability to recognize a wide range of antigens.

Associated Diseases

• Autoimmune diseases like rheumatoid arthritis, type 1 diabetes, and multiple sclerosis
• Infectious diseases like tuberculosis, HIV, and malaria
• Cancer susceptibility
• Organ transplant rejection

Did you know?

The HLA-DRB1 gene is highly polymorphic, meaning it has a large number of different alleles. This diversity contributes to the individual variation in immune responses.