HLA-DQB2

Description

The HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2) is a protein-coding gene located on chromosome 6.

HLA class II histocompatibility antigen, DX beta chain is a protein that in humans is encoded by the HLA-DQB2 gene.

HLA-DQB2, also known as HLA-DXB, is a protein that plays a crucial role in the immune system's recognition of foreign invaders. It acts as a "presenter" of antigens, which are small fragments of proteins from pathogens, to T cells. These T cells then mount an immune response to eliminate the pathogen. HLA-DQB2 forms a complex with another protein called HLA-DQA2, which is essential for its function. This complex binds to peptides (small protein fragments) derived from foreign invaders that have been taken up by antigen-presenting cells (APCs), like macrophages and dendritic cells. The complex then transports the peptide to the surface of the APC, where it can be recognized by CD4+ T cells. HLA-DQB2 also interacts with other proteins, including CD74, HLA-DM, and HLA-DO, to ensure that the correct peptide is presented to the T cell.

HLA-DQB2 is also known as DQB2, HLA-DQB1, HLA-DXB.

Associated Diseases

WES Whole Exome Sequencing