HIVEP2 : HIVEP zinc finger 2
Description
The HIVEP2 (HIVEP zinc finger 2) is a protein-coding gene located on chromosome 6.
The HIVEP2 gene provides instructions for making a protein that acts as a transcription factor. Transcription factors attach (bind) to specific regions of DNA and help control the activity (expression) of particular genes. The HIVEP2 protein is most abundant in the brain, where it regulates the expression of numerous genes, many of which are involved in brain growth and development. This protein may also participate in the function of immune system cells and the process of bone remodeling, in which old bone is broken down and new bone is created to replace it. It may also be involved in other body processes; however these additional roles are not completely understood.
HIVEP2 binds to the specific DNA sequence 5'-GGGACTTTCC-3' found within enhancer elements of various viral promoters, including those of SV40, CMV, and HIV1. Additionally, related sequences are present in the enhancer elements of numerous cellular promoters, such as those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may contribute to T-cell activation.
HIVEP2 is also known as HIV-EP2, MBP-2, MIBP1, MRD43, SHN2, ZAS2, ZNF40B.
