HIST3H2BB
Understanding HIST3H2BB: A Critical Gene in Chromatin Structure and Function
Description
HIST3H2BB is a core histone protein that plays a vital role in chromatin structure and gene regulation. Chromatin is the complex of DNA and proteins that make up chromosomes, and its organization is crucial for proper gene expression and cellular function.
HIST3H2BB is one of four histone H2B variants that are found in the nucleosome, the basic repeating unit of chromatin. Histones are responsible for packaging DNA into a compact structure that fits within the nucleus and for regulating access to DNA by transcription factors and other proteins.
Associated Diseases
Mutations in the HIST3H2BB gene have been linked to a number of diseases, including:
- Acute myeloid leukemia (AML): Mutations in HIST3H2BB are found in approximately 30% of AML cases, making it the most frequently mutated gene in this cancer.
- Myelodysplastic syndrome (MDS): Mutations in HIST3H2BB are also common in MDS, a group of blood disorders that can lead to AML.
- Chronic lymphocytic leukemia (CLL): HIST3H2BB mutations have been identified in a small percentage of CLL cases.
- Other cancers: Mutations in HIST3H2BB have been reported in various other types of cancer, including breast cancer, colon cancer, and lung cancer.
Did you Know ?
According to a study published in the journal Nature Genetics, HIST3H2BB mutations are estimated to occur in approximately 20% of all human cancers, making them among the most common genetic alterations in cancer.
