HIST2H2BE
HIST2H2BE: A Vital Histone Variant with Intriguing Roles
Description
HIST2H2BE is a histone variant that plays a crucial role in the structure and function of chromatin, the DNA-protein complex in eukaryotic cells. Unlike canonical histones, which are highly conserved, HIST2H2BE exhibits significant sequence variations across different organisms.
Associated Diseases
Dysregulation of HIST2H2BE has been implicated in various diseases, including:
- Cancer: Aberrant HIST2H2BE expression has been observed in several cancer types, contributing to tumor growth, invasion, and metastasis.
- Neurological Disorders: Mutations in HIST2H2BE have been linked to neurological disorders, such as Huntington's disease and spinocerebellar ataxia.
- Immune Disorders: Altered HIST2H2BE levels can affect immune cell function and contribute to autoimmune diseases.
Did you Know ?
Approximately 25% of human cancers exhibit abnormalities in HIST2H2BE expression, highlighting its significant role in disease development.
Latest Research
Recent research has shed light on the diverse functions of HIST2H2BE:
- Chromatin Structure: HIST2H2BE modulates chromatin architecture, affecting gene expression and DNA repair.
- Transcription Regulation: It interacts with transcription factors to influence gene transcription.
- DNA Replication and Repair: HIST2H2BE plays a role in DNA replication and damage response, ensuring genomic stability.
- Immune Regulation: It regulates the expression of immune-related genes, shaping immune cell activation and function.
