HIST1H2AB
Hist1h2ab: A Histone Deacetylase Enzyme Implicated in Gene Regulation and Disease
Description
Hist1h2ab is a histone deacetylase (HDAC) enzyme that belongs to the class I family of HDACs. It is responsible for removing acetyl groups from histone tails, which leads to chromatin condensation and reduced gene expression. Hist1h2ab is found in the nucleus of cells and plays a crucial role in regulating transcription by modulating chromatin structure.
Associated Diseases
Disruptions in Hist1h2ab function have been implicated in several diseases, including:
- Cancer: Overexpression of Hist1h2ab is associated with increased proliferation and migration of cancer cells. It has been found to promote the development and progression of various cancers, including breast cancer, lung cancer, and prostate cancer.
- Neurodegenerative diseases: Reduced Hist1h2ab activity has been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. This is because HDACs are involved in the regulation of neuronal survival and function.
- Cardiovascular disease: Hist1h2ab is involved in regulating blood vessel formation and function. Its dysregulation has been associated with the development of atherosclerosis and cardiovascular disease.
Did you Know ?
Studies have shown that overexpression of Hist1h2ab in breast cancer patients is associated with a decreased survival rate. This highlights the importance of HDACs as potential therapeutic targets for cancer treatment.
