HIST1H1C
Histone H1C: Insights into Chromatin Structure and Function
Description:
Histone H1C is a core histone protein that plays a crucial role in shaping the structure and function of chromatin, the DNA-containing material within eukaryotic cells. It is composed of a central globular domain flanked by two unstructured tails. H1C binds to the linker DNA regions between nucleosomes, the basic units of chromatin, to condense and stabilize the chromatin fiber.
Associated Diseases:
Mutations or dysregulation of H1C have been linked to various human diseases, including:
- Cancer: Alterations in H1C expression or modifications have been observed in several types of cancer, including breast, prostate, and lung cancer. These changes can affect chromatin structure, gene expression, and tumor progression.
- Neurodegenerative Diseases: H1C has been implicated in neurodegenerative conditions such as Alzheimer's disease and multiple sclerosis. Abnormal H1C modifications or interactions can contribute to neuronal dysfunction and cell death.
- Developmental Disorders: H1C mutations have been associated with developmental disorders including microcephaly (small head size) and intellectual disability. These mutations can affect chromatin dynamics and gene expression during embryonic development.
Did you Know ?
Approximately 5-10% of human histone H1 consists of the H1C variant, making it the least abundant of the core histones. Despite its relatively low abundance, H1C exerts significant effects on chromatin structure and gene regulation.
