HIRA
Description
The HIRA (histone cell cycle regulator) is a protein-coding gene located on chromosome 22.
The HIRA gene encodes the HIRA protein, which is located on chromosome 22. While its exact function remains unclear, HIRA is thought to be involved in gene regulation, chromatin metabolism, and histone modification. Studies suggest that HIRA proteins contribute to the resumption of transcription after ultraviolet C (UVC) damage. Its function can be effectively studied through siRNA knockdown, which has been independently validated. HIRA is considered a primary candidate gene in haploinsufficiency syndromes like DiGeorge syndrome, and insufficient HIRA production may disrupt normal embryonic development.
HIRA protein collaborates with ASF1A to facilitate chromatin assembly independent of DNA replication. It plays a crucial role in the periodic repression of histone gene transcription during the cell cycle. Furthermore, it is essential for the formation of senescence-associated heterochromatin foci (SAHF) and the efficient exit from the cell cycle during senescence.
HIRA is also known as DGCR1, TUP1, TUPLE1.
