HIPK1

Description

The HIPK1 (homeodomain interacting protein kinase 1) is a protein-coding gene located on chromosome 1.

Homeodomain-interacting protein kinase 1 is an enzyme that, in humans, is encoded by the HIPK1 gene. This protein belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. HIPK1 has been shown to interact with P53.

HIPK1 is a serine/threonine-protein kinase that plays a key role in transcription regulation and cellular apoptosis triggered by TNF. It acts as a corepressor for homeodomain transcription factors, phosphorylating DAXX and MYB. In response to stress, HIPK1 phosphorylates DAXX, causing its translocation from the nucleus to the cytoplasm. HIPK1 also inactivates MYB transcription factor activity through phosphorylation. In the absence of TNF, HIPK1 prevents MAP3K5-JNK activation. However, TNF triggers HIPK1's translocation to the cytoplasm in response to stress, leading to the activation of nuclear MAP3K5-JNK by derepression and promoting apoptosis. HIPK1 may be involved in anti-oxidative stress responses, and it plays a crucial role in regulating eye size, lens formation, and retinal lamination during late embryogenesis. Furthermore, HIPK1 promotes angiogenesis and is thought to be involved in erythroid differentiation. It may also contribute to the development of malignant squamous cell tumors. HIPK1 phosphorylates PAGE4 at 'Thr-51', which is essential for PAGE4's ability to enhance the transcriptional activator activity of JUN.

HIPK1 is also known as Myak, Nbak2.

Associated Diseases

WES Whole Exome Sequencing