HILPDA
Description
The HILPDA (hypoxia inducible lipid droplet associated) is a protein-coding gene located on chromosome 7.
HILPDA, also known as C7orf68 and HIG-2, is a protein encoded by the HILPDA gene in humans. It was discovered in a screen for genes activated by low oxygen pressure (hypoxia) in human cervical cancer cells. HILPDA is a small protein with 63 amino acids in humans and 64 amino acids in mice. It is produced by various cells and tissues, including cancer cells, immune cells, fat cells, and liver cells. Its expression is stimulated by low oxygen pressure, fatty acids, and beta-adrenergic agonists. HILPDA functions as a regulatory signal that blocks the breakdown of fat stores in cells when the external fat supply is high or oxygen availability is low. It is located in the endoplasmic reticulum and around lipid droplets. Studies have shown that HILPDA promotes fat storage in cancer cells, macrophages, and liver cells.
HILPDA is also known as C7orf68, HIG-2, HIG2.
Associated Diseases
- cancer
- acute kidney failure
- tuberculosis
- nonpapillary renal cell carcinoma
- colorectal cancer
- pachyonychia congenita
- type 2 diabetes mellitus
