HIC1
Description
The HIC1 (HIC ZBTB transcriptional repressor 1) is a protein-coding gene located on chromosome 17.
Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.
HIC1 is a transcriptional repressor that binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor and is involved in the development of head, face, limbs, and the ventral body wall. HIC1 down-regulates SIRT1, regulating p53/TP53-dependent apoptotic DNA-damage responses. Its specific target gene promoter association depends on corepressors such as CTBP1, CTBP2, and MTA1. In cooperation with MTA1, it represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. HIC1 is involved in regulating the Wnt signaling pathway by associating with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. It represses transcription from E2F1 and ATOH1, involving ARID1A, suggesting the participation of a distinct SWI/SNF-type chromatin-remodeling complex. HIC1 likely represses the transcription of ACKR3, FGFBP1, and EFNA1.
HIC1 is also known as ZBTB29, ZNF901, hic-1.
