HHLA3
HHLA3: An Overview
Description:
Human high-mobility group AT-hook 3 (HHLA3) is a protein involved in regulating gene expression. It binds to specific regions of DNA and helps shape the chromatin structure, which can influence the accessibility of genes to the machinery responsible for transcription. HHLA3 is highly conserved across species, suggesting it plays a crucial role in cellular function.
Associated Diseases:
Dysregulation of HHLA3 has been implicated in several diseases, including:
- Cancer: HHLA3 overexpression is associated with increased cell proliferation and invasion in various cancers, including breast, colorectal, and lung cancer.
- Cardiovascular disease: HHLA3 may contribute to the development of atherosclerosis by promoting inflammation and smooth muscle cell proliferation.
- Neurological disorders: Alterations in HHLA3 expression have been linked to Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
Did you Know ?
Studies have shown that HHLA3 overexpression is found in over 50% of breast cancer cases, highlighting its potential significance in cancer development.
