HES5
Description
The HES5 (hes family bHLH transcription factor 5) is a protein-coding gene located on chromosome 1.
HES5, encoded by the HES5 gene in humans, is a transcription factor that regulates the development of the early brain by maintaining neural stem cell progenitors in the ventricular zone. HES5 expression is significantly higher in squamous cervical carcinoma compared to CIN (cervical intraepithelial neoplasia) and also higher in CIN than in normal cervical epithelia. HES5 binds to the Notch receptor and its expression decreases during cartilage differentiation.
HES5 functions as a transcriptional repressor, inhibiting the expression of genes that rely on bHLH proteins for their activation. It plays a crucial role in regulating neurogenesis by acting as a negative regulator of this process.
HES5 is also known as bHLHb38.
Associated Diseases
- hearing loss, autosomal dominant 80
- autosomal recessive nonsyndromic hearing loss 4
- hearing loss, autosomal dominant 75
- hearing loss, autosomal dominant 77
- cancer
- choroideremia-deafness-obesity syndrome
- autosomal recessive cerebellar ataxia-blindness-deafness syndrome
- cochleosaccular degeneration-cataract syndrome
