HEPACAM2
Description
The HEPACAM2 (HEPACAM family member 2) is a protein-coding gene located on chromosome 7.
HEPACAM2 is a protein encoded by the HEPACAM2 gene in humans. It belongs to the immunoglobulin superfamily and is involved in mitosis. Its knockdown leads to prometaphase arrest, abnormal nuclear morphology, and apoptosis. Poly (ADP-ribosylation) of HEPACAM2 promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion involving the HEPACAM2 gene could be associated with myeloid leukemia and myelodysplastic syndrome in human patients.
HEPACAM2 plays a crucial role in ensuring proper chromosome segregation during cell division. It is required during prometaphase, a stage of mitosis, for centrosome maturation. This process involves the protein undergoing a modification called poly-ADP-ribosylation (PARsylation) by the enzyme TNKS. Following PARsylation, HEPACAM2 translocates from the Golgi apparatus to mitotic centrosomes. At the centrosomes, HEPACAM2 anchors AKAP9/CG-NAP, a scaffold protein that is part of the gamma-tubulin ring complex. This interaction is essential for the formation of robust microtubules, which are responsible for moving chromosomes during cell division.
HEPACAM2 is also known as MIKI.
