HENMT1
Description
The HENMT1 (HEN methyltransferase 1) is a protein-coding gene located on chromosome 1.
HENMT1 is a methyltransferase enzyme that modifies piRNAs, a class of small RNAs essential for regulating transposon activity. It adds a 2'-O-methyl group to the 3'-end of piRNAs, preventing degradation by uridylation. This stabilization is crucial for maintaining the piRNA pool, which is essential for proper gametogenesis.
HENMT1 is also known as C1orf59, HEN1.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 65
- spermatogenic failure 11
- spermatogenic failure 10
- spermatogenic failure, X-linked, 3
- spermatogenic failure 40
- spermatogenic failure 47
- spermatogenic failure 72
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure 46
- spermatogenic failure 45
- spermatogenic failure 49
- spermatogenic failure 43
- spermatogenic failure 19
- spermatogenic failure 39
- spermatogenic failure 41
- spermatogenic failure 63
- spermatogenic failure 25
