HEMGN
Description
The HEMGN (hemogen) is a protein-coding gene located on chromosome 9.
Hemogen is a protein that in humans is encoded by the HEMGN gene.
Hemogen regulates the proliferation and differentiation of hematopoietic cells. Overexpression of Hemogen inhibits TPA-induced megakaryocytic differentiation in the K562 cell model. Hemogen may also prevent cell apoptosis by activating the nuclear factor-kappa B (NF-kB).
HEMGN is also known as CT155, EDAG, EDAG-1, NDR.
Associated Diseases
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- alpha thalassemia-intellectual disability syndrome type 1
- delta-beta-thalassemia
- hemoglobin E-beta-thalassemia syndrome
- hemoglobin D disease
- hemolytic anemia due to adenylate kinase deficiency
- Heinz body anemia
- hemoglobin C-beta-thalassemia syndrome
- alpha-thalassemia-myelodysplastic syndrome
