HEBP1
Description
The HEBP1 (heme binding protein 1) is a protein-coding gene located on chromosome 12.
HEBP1 is a protein encoded by the HEBP1 gene in humans. It is an intracellular tetrapyrrole-binding protein with a 21-amino acid N-terminal chemoattractant peptide. This peptide is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.
HEBP1 is involved in the removal of potentially toxic porphyrinogens from the cell by binding to them with high affinity. It binds equally well to heme, metalloporphyrins, free porphyrins, and N-methylprotoporphyrin.
HEBP1 is also known as HBP, HEBP.
