HDGFRP3
HDRFP3: A Versatile Protein with Implications in Metabolism, Disease, and Beyond
Description
HDRFP3 (Heparin-binding defensin-related peptide 3) is a small, cationic antimicrobial peptide that is mainly secreted by specialized neutrophils known as Paneth cells in the small intestine. It plays a pivotal role in maintaining a healthy mucosal microbiome by eliminating potential pathogens. HDRFP3 possesses both antimicrobial and immunomodulatory properties, making it an essential component of the host's innate immune defense.
Associated Diseases
Dysregulation of HDRFP3 has been linked to various human diseases, including:
- Inflammatory bowel disease (IBD): Reduced levels of HDRFP3 have been observed in patients with Crohn's disease and ulcerative colitis, suggesting its role in dampening intestinal inflammation.
- Cystic fibrosis: Individuals with cystic fibrosis exhibit decreased production of HDRFP3, contributing to the impaired immune response and chronic lung infections.
- Colon cancer: Low HDRFP3 expression has been associated with increased risk of colon cancer, highlighting its potential as a tumor suppressor.
- Metabolic syndrome: HDRFP3 has been shown to impact glucose metabolism and insulin sensitivity, suggesting a possible link to type 2 diabetes and metabolic disorders.
Did you Know ?
According to a study published in the journal "Gastroenterology," HDRFP3 levels were found to be significantly lower in individuals with Crohn's disease compared to healthy controls. Moreover, patients with the lowest HDRFP3 levels had a higher risk of developing disease flares.
