HDAC10
Description
The HDAC10 (histone deacetylase 10) is a protein-coding gene located on chromosome 22.
HDAC10 is an enzyme encoded by the HDAC10 gene in humans. It plays a role in regulating gene expression by modifying chromatin structure through histone acetylation. HDAC10 counteracts the activity of histone acetyltransferases, which add acetyl groups to histones. HDAC10 has been shown to interact with HDAC2 and NCOR2.
HDAC10 primarily deacetylates polyamines, particularly N(8)-acetylspermidine, and to a lesser extent acetylcadaverine and acetylputrescine. It exhibits reduced activity towards N(1),N(8)-diacetylspermidine and minimal activity, if any, towards N(1)-acetylspermidine. While HDAC10 has demonstrated histone deacetylase activity in vitro, its physiological significance remains unclear. It has been implicated in MSH2 deacetylation and may contribute to late-stage autophagy, potentially promoting autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. Additionally, HDAC10 might play roles in homologous recombination and DNA mismatch repair.
HDAC10 is also known as HD10.
Associated Diseases
- T-cell non-Hodgkin lymphoma
- graft versus host disease
- breast cancer
- lung cancer
- endometrial cancer
- low grade glioma
