HCN2
Description
The HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2) is a protein-coding gene located on chromosome 19.
HCN2, or Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2, is a protein encoded by the HCN2 gene in humans. Its function is not fully understood, but it is known to be activated by hyperpolarization and plays a role in the spontaneous generation of electrical rhythm in the sinoatrial node of the heart. It has also been implicated in chronic pain. HCN2 interacts with HCN1 and HCN4.
HCN2 is a hyperpolarization-activated ion channel that exhibits weak selectivity for potassium over sodium ions. It contributes to the native pacemaker currents in the heart (If) and in neurons (Ih). HCN2 can also transport ammonium in the distal nephron. It produces a large instantaneous current and is modulated by intracellular chloride ions and pH, with acidic pH shifting the activation to more negative voltages.
HCN2 is also known as BCNG-2, BCNG2, EIG17, FEB2, GEFSP11, HAC-1.
