HCLS1

Description

The HCLS1 (hematopoietic cell-specific Lyn substrate 1) is a protein-coding gene located on chromosome 3.

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene. HCLS1 has been shown to interact with Caspase 3.

HCLS1 is a substrate of the antigen receptor-coupled tyrosine kinase. It plays a role in antigen receptor signaling, affecting both clonal expansion and deletion in lymphoid cells. It may also be involved in the regulation of gene expression.

HCLS1 is also known as CTTNL, HS1, lckBP1, p75.

Associated Diseases

• asthma
• combined immunodeficiency with skin granulomas
• severe combined immunodeficiency due to CARD11 deficiency
• severe combined immunodeficiency due to CTPS1 deficiency
• common variable immunodeficiency
• classic Hodgkin lymphoma
• immunodeficiency 18
• hyper-IgM syndrome type 3
• isolated agammaglobulinemia
• BENTA disease
• immunodeficiency 62
• reticular dysgenesis
• immunodeficiency, common variable, 14
• immunodeficiency 105