HBG2
Description
The HBG2 (hemoglobin subunit gamma 2) is a protein-coding gene located on chromosome 11.
Hemoglobin subunit gamma-2 is a protein encoded by the HBG2 gene in humans. It is typically expressed in the fetal liver, spleen, and bone marrow. Two gamma chains and two alpha chains combine to form fetal hemoglobin (HbF), which is usually replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production persists into adulthood. The two gamma chain types differ at residue 136, with glycine in the G-gamma product (HBG2) and alanine in the A-gamma product (HBG1). The G-gamma chain predominates at birth. The beta-globin cluster gene order is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.
HBG2 is also known as HBG-T1, TNCY.
Associated Diseases
- Cyanosis, transient neonatal
- Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
- Fetal hemoglobin quantitative trait locus 1
- Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
