HAPLN4
Description
The HAPLN4 (hyaluronan and proteoglycan link protein 4) is a protein-coding gene located on chromosome 19.
HAPLN4 is a human gene that encodes a protein known as hyaluronan and proteoglycan link protein 4. This protein is a member of the hyaluronan-binding protein family, which are important for the structure and function of the extracellular matrix (ECM). The ECM is a complex network of proteins and other molecules that surrounds cells and provides support and organization to tissues. HAPLN4 plays a role in regulating the ECM, particularly by interacting with hyaluronan (HA), a major component of the ECM. HA is a long, unbranched polysaccharide that helps to hold water and provide cushioning and lubrication to tissues. HAPLN4 is thought to help to organize HA into specific structures within the ECM, which may be important for various cellular processes, such as cell migration and adhesion. HAPLN4 is also involved in the formation of pericellular matrices, which are specialized areas of the ECM that surround cells. The exact functions of HAPLN4 are still being investigated, but it is clear that it plays a significant role in the structure and function of the ECM. Mutations in the HAPLN4 gene have been linked to certain diseases, such as osteoarthritis.
HAPLN4 encodes a protein that is a member of the hyaluronan-binding protein family. It is a large, multimeric protein that is found in the extracellular matrix (ECM) of various tissues, including cartilage, skin, and bone. HAPLN4 plays a role in regulating ECM organization and function. Specifically, it interacts with hyaluronan (HA), a major component of the ECM, and contributes to the formation of HA-rich pericellular matrices. HAPLN4 is also involved in cell adhesion and migration. Its expression is regulated during development and in response to injury. Studies have suggested that HAPLN4 may be involved in the pathogenesis of certain diseases, such as osteoarthritis and cancer.
HAPLN4 is also known as BRAL2.
