H19 : H19 imprinted maternally expressed transcript

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Description

The H19 gene, located on chromosome 11p15.5, stands as a critical player in human development, showcasing both maternally imprinted expression and a complex role in various diseases. Its primary transcript acts as a long non-coding RNA (lncRNA), influencing gene regulation and cell fate. H19‘s expression is tightly controlled by genomic imprinting, with only the maternal copy being active. This gene serves as a crucial regulator of growth, development, and cellular processes, intricately linked to several human diseases.

Associated Diseases

• Beckwith-Wiedemann Syndrome (BWS)
• Silver-Russell Syndrome (SRS)
• Wilms Tumor
• Hepatoblastoma
• Rhabdomyosarcoma
• Neuroblastoma
• Diabetic nephropathy
• Obesity
• Cancer

Did you know?

H19‘s expression is inversely correlated with IGF2 expression, a key growth factor, highlighting the gene‘s intricate role in growth regulation.