GTF3C4

---

Description

The GTF3C4 (general transcription factor IIIC subunit 4) is a protein-coding gene located on chromosome 9.

General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the GTF3C4 gene.

== Interactions == GTF3C4 has been shown to interact with GTF3C2, GTF3C1, POLR3C and GTF3C5.

GTF3C4 is crucial for RNA polymerase III‘s production of various small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA from both cellular and viral origins. GTF3C4 possesses histone acetyltransferase (HAT) activity, uniquely targeting free and nucleosomal H3. It may collaborate with GTF3C5 to recruit TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C, and POLR3F. GTF3C4 might be located near the A box.

GTF3C4 is also known as KAT12, TF3C-delta, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA.