GTF3A

---

Description

The GTF3A (general transcription factor IIIA) is a protein-coding gene located on chromosome 13.

GTF3A encodes Transcription factor IIIA (TFIIIA), a protein first discovered in 1980 by Roeder and further characterized in 1988 by Wolffe and Brown. TFIIIA was the first zinc finger protein identified in Xenopus. It plays a crucial role in the formation of the large ribosomal subunit. It binds to the internal control region (ICR) of 5S ribosomal RNA genes, which is about 50 base pairs long, and is essential for their transcription by RNA polymerase III. It may also contribute to the regulation of other gene transcription. TFIIIA also binds to the transcribed 5S RNA.

GTF3A is also known as AP2, TFIIIA.