GTF2I : general transcription factor IIi
Description
The GTF2I (general transcription factor IIi) is a protein-coding gene located on chromosome 7.
The GTF2I gene produces two proteins: TFII-I and BAP-135. TFII-I acts as a transcription factor by binding to specific DNA regions and regulating the activity of other genes. It is active in the brain and various tissues, playing a role in cell growth and division, calcium regulation, and myelination, the formation of the myelin sheath around nerve cells. BAP-135 is found in B cells and is activated during B cell maturation and antibody production in response to foreign substances.
GTF2I plays a crucial role in regulating gene expression by coordinating the assembly of a multiprotein complex at the C-FOS promoter. This complex links specific signal-responsive activator complexes to the basal transcription machinery. GTF2I also promotes the formation of stable complexes between SRF and PHOX1, and cooperatively interacts with PHOX1 to activate serum-induced transcription of a reporter gene driven by the C-FOS serum response element (SRE). Furthermore, GTF2I acts as a coregulator for USF1 by independently binding to two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. This gene is essential for forming functional ARID3A DNA-binding complexes, which are required for activating immunoglobulin heavy-chain transcription during B-lymphocyte activation.
GTF2I is also known as BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6.
