GTF2H1
Description
The GTF2H1 (general transcription factor IIH subunit 1) is a protein-coding gene located on chromosome 11.
General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene. GTF2H1 has been shown to interact with Transcription Factor II H
GTF2H1 is a core component of the Transcription Factor IIH (TFIIH) complex, which plays a crucial role in both DNA repair and RNA transcription. In DNA repair, specifically nucleotide excision repair (NER), TFIIH helps to open the DNA around damaged regions, allowing for the removal of the damaged segment and its replacement with a new fragment. In RNA transcription, TFIIH is essential for the initiation process. Once the pre-initiation complex (PIC) is formed, TFIIH facilitates promoter opening and allows RNA polymerase II to escape the promoter. This process is regulated by the CAK module, which phosphorylates the C-terminal tail (CTD) of RNA polymerase II.
GTF2H1 is also known as BTF2, P62, TFB1, TFIIH.
